Publication type
Journal Article
Authors
- Karoline Kuchenbaecker
- Nikita Telkar
- Theresa Reiker
- Robin G. Walters
- Kuang Lin
- Anders Eriksson
- Deepti Gurdasani
- Arthur Gilly
- Lorraine Southam
- Emmanouil Tsafantakis
- Maria Karaleftheri
- Janet Seeley
- Anatoli Kamali
- Gershim Asiki
- Iona Y. Millwood
- Michael Holmes
- Huaidong Du
- Yu Guo
- Meena Kumari
- George Dedoussis
- Liming Li
- Zhengming Chen
- Manjinder S. Sandhu
- Eleftheria Zeggini
Publication date
September 24, 2019
Summary:
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p < 1.9 × 10−14). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
Published in
Nature Communications
Volume
Volume: 10:4330
DOI
https://doi.org/10.1038/s41467-019-12026-7
ISSN
20411723
Subjects
Notes
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Open Access
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