Publication type
Journal Article
Authors
Publication date
January 15, 2017
Abstract:
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
Published in
Nature Genetics
Volume and page numbers
Volume: 49 , p.403 -415
DOI
http://dx.doi.org/10.1038/ng.3768
ISSN
10614036
Subjects
Notes
Not held in Hilary Doughty Research Library - bibliographic reference only
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