Publication type
Journal Article
Authors
- Maarten Leusink
- Anke H. Maitland-van der Zee
- Bo Ding
- Fotios Drenos
- Erik P. A. van Iperen
- Helen R. Warren
- Mark J. Caulfield
- L. Adrienne Cupples
- Mary Cushman
- Aroon D. Hingorani
- Ron C. Hoogeveen
- G. Kees Hovingh
- Meena Kumari
- Leslie A. Lange
- Patricia B. Munroe
- Fredrik Nyberg
- Pamela J. Schreiner
- Suthesh Sivapalaratnam
- Paul I. W. de Bakker
- Anthonius de Boer
- Brendan J. Keating
- Folkert W. Asselbergs
- N. Charlotte Onland-Moret
Publication date
April 15, 2016
Summary:
Aim: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. Patients and methods: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10-4 (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. Results: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171–0.0617, p = 5.37 × 10-4). Conclusion: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.
Published in
Pharmacogenomics
Volume and page numbers
Volume: 17 , p.583 -591
DOI
http://dx.doi.org/10.2217/pgs.16.8
ISSN
14622416
Subjects
Notes
Not held in Research Library - bibliographic reference only
#523712