Publication type
Journal Article
Authors
- Yingchang Lu
- Felix R. Day
- Stefan Gustafsson
- Martin L. Buchkovich
- Jianbo Na
- Diana L. Cousminer
- Zari Dastani
- Alexander W. Drong
- Tonu Esko
- David M. Evans
- Mario Falchi
- Mary F. Feitosa
- Teresa Ferreira
- Asa K. Hedman
- Robin Haring
- Pirro G. Hysi
- Mark M. Iles
- Anne E. Justice
- Stavroula Kanoni
- Vasiliki Lagou
- Rui Li
- Xin Li
- Adam Locke
- Chen Lu
- Reedik Mägi
- John R.B. Perry
- Tune H. Pers
- Qibin Qi
- Marianna Sanna
- Ellen M. Schmidt
- William R. Scott
- Dmitry Shungin
- Alexander Teumer
- Anna A.E. Vinkhuyzen
- Ryan W. Walker
- Harm-Jan Westra
- Mingfeng Zhang
- Weihua Zhang
- Jing Hua Zhao
- Zhihong Zhu
- Uzma Afzal
- Tarunveer Singh Ahluwalia
- Stephan J. L. Bakker
- Claire Bellis
- Amélie Bonnefond
- Katja Borodulin
- Aron S. Buchman
- Tommy Cederholm
- Audrey C. Choh
- Hyung Jin Choi
- Joanne E. Curran
- Lisette C.P.G.M. de Groot
- Philip L. De Jager
- Rosalie A.M. Dhonukshe-Rutten
- Anke W. Enneman
- Elodie Eury
- Daniel S. Evans
- Tom Forsen
- Nele Friedrich
- Frederic Fumeron
- Melissa E. Garcia
- Simone Gartner
- Bok-Ghee Han
- Aki S. Havulinna
- Caroline Hayward
- Dena Hernandez
- Hans Hillege
- Till Ittermann
- Jack W. Kent
- Ivana Kolcic
- Tiina Laatikainen
- Jari Lahti
- Irene Mateo Leach
- Christine G. Lee
- Jong-Young Lee
- Tian Liu
- Youfang Liu
- Stéphane Lobbens
- Marie Loh
- Leo-Pekka Lyytikainen
- Carolina Medina-Gomez
- Karl Michaëlsson
- Mike A. Nalls
- Carrie M. Nielson
- Laticia Oozageer
- Laura Pascoe
- Lavinia Paternoster
- Ozren Polasek
- Samuli Ripatti
- Mark A. Sarzynski
- Chan Soo Shin
- Nina Smolej Narancic
- Dominik Spira
- Priya Srikanth
- Elisabeth Steinhagen-Thiessen
- Yun Ju Sung
- Karin M.A. Swart
- Leena Taittonen
- Toshiko Tanaka
- Emmi Tikkanen
- Nathalie van der Velde
- Natasja M. van Schoor
- Niek Verweij
- Alan F. Wright
- Lei Yu
- Joseph M. Zmuda
- Niina Eklund
- Terrence Forrester
- Niels Grarup
- Anne U. Jackson
- Kati Kristiansson
- Teemu Kuulasmaa
- Johanna Kuusisto
- Peter Lichtner
- Jian'an Luan
- Anubha Mahajan
- Satu Männistö
- Cameron D. Palmer
- Janina S. Ried
- Robert A. Scott
- Alena Stancakova
- Peter J. Wagner
- Ayse Demirkan
- Angela Doring
- Vilmundur Gudnason
- Douglas P. Kiel
- Brigitte Kuhnel
- Massimo Mangino
- Barbara McKnight
- Cristina Menni
- Jeffrey R. O'Connell
- Ben A. Oostra
- Alan R. Shuldiner
- Kijoung Song
- Liesbeth Vandenput
- Cornelia M. van Duijn
- Peter Vollenweider
- Charles C. White
- Yvonne Boettcher
- Richard S. Cooper
- Nita G. Forouhi
- Christian Gieger
- Harald Grallert
- Aroon Hingorani
- Torben Jorgensen
- Pekka Jousilahti
- Mika Kivimaki
- Meena Kumari
- Claudia Langenberg
- Allan Linneberg
- Amy Luke
- Colin A. McKenzie
- Aarno Palotie
- Oluf Pedersen
- Annette Peters
- Konstantin Strauch
- Bamidele O. Tayo
- Nicholas J. Wareham
- David A. Bennett
- Lars Bertram
- John Blangero
- Matthias Bluher
- Claude Bouchard
- Harry Campbell
- Nam H. Cho
- Steven R. Cummings
- Stefan A. Czerwinski
- Ilja Demuth
- Rahel Eckardt
- Johan G. Eriksson
- Luigi Ferrucci
- Oscar H. Franco
- Philippe Froguel
- Ron T. Gansevoort
- Torben Hansen
- Tamara B. Harris
- Nicholas Hastie
- Markku Heliovaara
- Albert Hofman
- Joanne M. Jordan
- Antti Jula
- Mika Kahonen
- Eero Kajantie
- Paul B. Knekt
- Seppo Koskinen
- Peter Kovacs
- Terho Lehtimaki
- Lars Lind
- Yongmei Liu
- Eric S. Orwoll
- Clive Osmond
- Markus Perola
- Louis Perusse
- Olli T. Raitakari
- Tuomo Rankinen
- D.C. Rao
- Treva K. Rice
- Fernando Rivadeneira
- Igor Rudan
- Veikko Salomaa
- Thorkild I. A. Sørensen
- Michael Stumvoll
- Anke Tonjes
- Bradford Towne
- Gregory J. Tranah
- Angelo Tremblay
- Andre G. Uitterlinden
- Pim van der Harst
- Erkki Vartiainen
- Jorma S. Viikari
- Veronique Vitart
- Marie-Claude Vohl
- Henry Volzke
- Mark Walker
- Henri Wallaschofski
- Sarah Wild
- James F. Wilson
- Loic Yengo
- D. Timothy Bishop
- Ingrid B. Borecki
- John C. Chambers
- L. Adrienne Cupples
- Abbas Dehghan
- Panos Deloukas
- Ghazaleh Fatemifar
- Caroline Fox
- Terrence S. Furey
- Lude Franke
- Jiali Han
- David J. Hunter
- Juha Karjalainen
- Fredrik Karpe
- Robert C. Kaplan
- Jaspal S. Kooner
- Mark I. McCarthy
- Joanne M. Murabito
- Andrew P. Morris
- Julia A.N. Bishop
- Kari E. North
- Claes Ohlsson
- Ken K. Ong
- Inga Prokopenko
- J. Brent Richards
- Eric E. Schadt
- Tim D. Spector
- Elisabeth Widen
- Cristen J. Willer
- Jian Yang
- Erik Ingelsson
- Karen L. Mohlke
- Joel N. Hirschhorn
- John Andrew Pospisilik
- M. Carola Zillikens
- Cecilia Lindgren
- Tuomas Oskari Kilpelainen
- Ruth J. F. Loos
Publication date
February 1, 2016
Summary:
To increase our understanding of the genetic basis of adiposity and its
links to cardiometabolic disease risk, we conducted a genome-wide
association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF%
showed distinct cross-phenotype association signatures with a range of
cardiometabolic traits revealing new insights in the link between
adiposity and disease risk.
Published in
Nature Communications
Volume
Volume: 7:10495
DOI
http://dx.doi.org/10.1038/ncomms10495
ISSN
20411723
Subjects
Notes
Open Access article
#523585