Publication type
Journal Article
Authors
- Thomas W. Winkler
- Anne E. Justice
- Mariaelisa Graff
- Llilda Barata
- Mary F. Feitosa
- Su Chu
- Jacek Czajkowski
- Tonu Esko
- Tove Fall
- Tuomas O. Kilpeläinen
- Reedik Mägi
- Evelin Mihailov
- Tune H. Pers
- Sina Rüeger
- Alexander Teumer
- Georg B. Ehret
- Teresa Ferreira
- Nancy L. Heard-Costa
- Juha Karjalainen
- Vasiliki Lagou
- Anubha Mahajan
- Michael D. Neinast
- Inga Prokopenko
- Jeannette Simino
- Tanya M. Teslovich
- Rick Jansen
- Harm-Jan Westra
- Charles C. White
- Devin Absher
- Tarunveer Singh Ahluwalia
- Shafqat Ahmad
- Eva Albrecht
- Alexessander Couto Alves
- Jennifer L. Bragg-Gresham
- Anton J. M. de Craen
- Joshua C. Bis
- Amélie Bonnefond
- Gabrielle Boucher
- Gemma Cadby
- Yu-Ching Cheng
- Charleston W. K. Chiang
- Graciela Delgado
- Ayse Demirkan
- Nicole Dueker
- Niina Eklund
- Gudny Eiriksdottir
- Joel Eriksson
- Bjarke Feenstra
- Krista Fischer
- Francesca Frau
- Tessel E. Galesloot
- Frank Geller
- Anuj Goel
- Mathias Gorski
- Tanja B. Grammer
- Stefan Gustafsson
- Saskia Haitjema
- Jouke-Jan Hottenga
- Jennifer E. Huffman
- Anne U. Jackson
- Kevin B. Jacobs
- Åsa Johansson
- Marika Kaakinen
- Marcus E. Kleber
- Jari Lahti
- Irene Mateo Leach
- Benjamin Lehne
- Youfang Liu
- Ken Sin Lo
- Mattias Lorentzon
- Jian'an Luan
- Pamela A.F. Madden
- Massimo Mangino
- Barbara McKnight
- Carolina Medina-Gomez
- Keri L. Monda
- May E. Montasser
- Gabriele Müller
- Martina Müller-Nurasyid
- Ilja M. Nolte
- Kalliope Panoutsopoulou
- Laura Pascoe
- Lavinia Paternoster
- Nigel W. Rayner
- Frida Renström
- Federica Rizzi
- Lynda M. Rose
- Kathy A. Ryan
- Perttu Salo
- Serena Sanna
- Hubert Scharnagl
- Jianxin Shi
- Albert Vernon Smith
- Lorraine Southam
- Alena Stančáková
- Valgerdur Steinthorsdottir
- Rona J. Strawbridge
- Yun Ju Sung
- Ioanna Tachmazidou
- Toshiko Tanaka
- Gudmar Thorleifsson
- Stella Trompet
- Natalia Pervjakova
- Jonathan P. Tyrer
- Liesbeth Vandenput
- Sander W. van der Laan
- Nathalie van der Velde
- Jessica van Setten
- Jana V. van Vliet-Ostaptchouk
- Niek Verweij
- Efthymia Vlachopoulou
- Lindsay L. Waite
- Sophie R. Wang
- Zhaoming Wang
- Sarah H. Wild
- Christina Willenborg
- James F. Wilson
- Andrew Wong
- Jian Yang
- Loïc Yengo
- Laura M. Yerges-Armstrong
- Lei Yu
- Weihua Zhang
- Jing Hua Zhao
- Ehm A. Andersson
- Stephan J. L. Bakker
- Damiano Baldassarre
- Karina Banasik
- Matteo Barcella
- Cristina Barlassina
- Claire Bellis
- Paola Benaglio
- John Blangero
- Matthias Blüher
- Fabrice Bonnet
- Lori L. Bonnycastle
- Heather A. Boyd
- Marcel Bruinenberg
- Aron S. Buchman
- Harry Campbell
- Yii-Der Ida Chen
- Peter S. Chines
- Simone Claudi-Boehm
- John Cole
- Francis S. Collins
- Eco J.C. de Geus
- Lisette C.P.G.M. de Groot
- Maria Dimitriou
- Jubao Duan
- Stefan Enroth
- Elodie Eury
- Aliki-Eleni Farmaki
- Nita G. Forouhi
- Nele Friedrich
- Pablo V. Gejman
- Bruna Gigante
- Nicola Glorioso
- Alan S. Go
- Omri Gottesman
- Jürgen Gräßler
- Harald Grallert
- Niels Grarup
- Yu-Mei Gu
- Linda Broer
- Annelies C. Ham
- Torben Hansen
- Tamara B. Harris
- Catharina A. Hartman
- Maija Hassinen
- Nicholas Hastie
- Andrew T. Hattersley
- Andrew C. Heath
- Anjali K. Henders
- Dena Hernandez
- Hans Hillege
- Oddgeir Holmen
- Kees G. Hovingh
- Jennie Hui
- Lise L. Husemoen
- Nina Hutri-Kähönen
- Pirro G. Hysi
- Thomas Illig
- Philip L. De Jager
- Shapour Jalilzadeh
- Torben Jørgensen
- Markus Juonala
- Stavroula Kanoni
- Maria Karaleftheri
- Kay Tee Khaw
- Leena Kinnunen
- Steven J. Kittner
- Wolfgang Koenig
- Ivana Kolcic
- Peter Kovacs
- Nikolaj T. Krarup
- Wolfgang Kratzer
- Janine Krüger
- Diana Kuh
- Meena Kumari
- Theodosios Kyriakou
- Claudia Langenberg
- Lars Lannfelt
- Chiara Lanzani
- Vaneet Lotay
- Lenore J. Launer
- Karin Leander
- Jaana Lindström
- Allan Linneberg
- Yan-Ping Liu
- Stéphane Lobbens
- Robert Luben
- Valeriya Lyssenko
- Satu Männistö
- Patrik K. Magnusson
- Wendy L. McArdle
- Cristina Menni
- Sigrun Merger
- Lili Milani
- Grant W. Montgomery
- Andrew P. Morris
- Narisu Narisu
- Mari Nelis
- Ken K. Ong
- Aarno Palotie
- Louis Pérusse
- Irene Pichler
- Maria G. Pilia
- Anneli Pouta
- Myriam Rheinberger
- Rasmus Ribel-Madsen
- Marcus Richards
- Kenneth M. Rice
- Treva K. Rice
- Carlo Rivolta
- Veikko Salomaa
- Alan R. Sanders
- Mark A. Sarzynski
- Salome Scholtens
- Robert A. Scott
- William R. Scott
- Sylvain Sebert
- Sebanti Sengupta
- Bengt Sennblad
- Thomas Seufferlein
- Angela Silveira
- P. Eline Slagboom
- Jan H. Smit
- Thomas H. Sparsø
- Kathleen Stirrups
- Ronald P. Stolk
- Heather M. Stringham
- Morris A. Swertz
- Amy J. Swift
- Ann-Christine Syvänen
- Sian-Tsung Tan
- Barbara Thorand
- Anke Tönjes
- Angelo Tremblay
- Emmanouil Tsafantakis
- Peter J. van der Most
- Uwe Völker
- Marie-Claude Vohl
- Judith M. Vonk
- Melanie Waldenberger
- Ryan W. Walker
- Roman Wennauer
- Elisabeth Widén
- Gonneke Willemsen
- Tom Wilsgaard
- Alan F. Wright
- M. Carola Zillikens
- Suzanne C. van Dijk
- Natasja M. van Schoor
- Folkert W. Asselbergs
- Paul I. W. de Bakker
- Jacques S. Beckmann
- John Beilby
- David A. Bennett
- Richard N. Bergman
- Sven Bergmann
- Carsten A. Böger
- Bernhard O. Boehm
- Eric Boerwinkle
- Dorret I. Boomsma
- Stefan R. Bornstein
- Erwin P. Bottinger
- Claude Bouchard
- John C. Chambers
- Stephen J. Chanock
- Daniel I. Chasman
- Francesco Cucca
- George Dedoussis
- Jeanette Erdmann
- Johan G. Eriksson
- Denis A. Evans
- Ulf de Faire
- Martin Farrall
- Luigi Ferrucci
- Ian Ford
- Lude Franke
- Paul W. Franks
- Philippe Froguel
- Ron T. Gansevoort
- Christian Gieger
- Henrik Grönberg
- Vilmundur Gudnason
- Ulf Gyllensten
- Per Hall
- Anders Hamsten
- Pim van der Harst
- Caroline Hayward
- Markku Heliövaara
- Christian Hengstenberg
- Andrew A. Hicks
- Aroon Hingorani
- Albert Hofman
- Frank Hu
- Heikki V. Huikuri
- Kristian Hveem
- Alan L. James
- Joanne M. Jordan
- Antti Jula
- Mika Kähönen
- Eero Kajantie
- Sekar Kathiresan
- Lambertus A.L.M. Kiemeney
- Mika Kivimaki
- Paul B. Knekt
- Heikki A. Koistinen
- Jaspal S. Kooner
- Seppo Koskinen
- Johanna Kuusisto
- Winfried Maerz
- Nicholas G. Martin
- Markku Laakso
- Timo A. Lakka
- Terho Lehtimäki
- Guillaume Lettre
- Douglas F. Levinson
- Lars Lind
- Marja-Liisa Lokki
- Pekka Mäntyselkä
- Mads Melbye
- Andres Metspalu
- Braxton D. Mitchell
- Frans L. Moll
- Jeffrey C. Murray
- Arthur W. Musk
- Markku S. Nieminen
- Inger Njølstad
- Claes Ohlsson
- Albertine J. Oldehinkel
- Ben A. Oostra
- Lyle J. Palmer
- James S. Pankow
- Gerard Pasterkamp
- Nancy L. Pedersen
- Oluf Pedersen
- Brenda W. Penninx
- Markus Perola
- Annette Peters
- Ozren Polasek
- Peter P. Pramstaller
- Bruce M. Psaty
- Lu Qi
- Thomas Quertermous
- Olli T. Raitakari
- Tuomo Rankinen
- Rainer Rauramaa
- Paul M. Ridker
- John D. Rioux
- Fernando Rivadeneira
- Jerome I. Rotter
- Igor Rudan
- Hester M. den Ruijter
- Juha Saltevo
- Naveed Sattar
- Heribert Schunkert
- Peter E.H. Schwarz
- Alan R. Shuldiner
- Juha Sinisalo
- Harold Snieder
- Thorkild I. A. Sørensen
- Tim D. Spector
- Jan A. Staessen
- Stefania Bandinelli
- Unnur Thorsteinsdottir
- Michael Stumvoll
- Jean-Claude Tardif
- Elena Tremoli
- Jaakko Tuomilehto
- André G. Uitterlinden
- Matti Uusitupa
- André L.M. Verbeek
- Sita H. Vermeulen
- Jorma S. Viikari
- Veronique Vitart
- Henry Völzke
- Peter Vollenweider
- Gérard Waeber
- Mark Walker
- Henri Wallaschofski
- Nicholas J. Wareham
- Hugh Watkins
- Eleftheria Zeggini
- Aravinda Chakravarti
- Deborah J. Clegg
- L. Adrienne Cupples
- Penny Gordon-Larsen
- Cashell E. Jaquish
- D.C. Rao
- Goncalo R. Abecasis
- Themistocles L. Assimes
- Inês Barroso
- Sonja I. Berndt
- Michael Boehnke
- Panos Deloukas
- Caroline S. Fox
- Leif C. Groop
- David J. Hunter
- Erik Ingelsson
- Robert C. Kaplan
- Mark I. McCarthy
- Karen L. Mohlke
- Jeffrey R. O'Connell
- David Schlessinger
- David P. Strachan
- Kari Stefansson
- Cornelia M. van Duijn
- Joel N. Hirschhorn
- Cecilia M. Lindgren
- Iris M. Heid
- Kari E. North
- Ingrid B. Borecki
- Zoltán Kutalik
- Ruth J. F. Loos
Publication date
October 15, 2015
Summary:
Adult body size and body shape differ substantially between men and women and change over time. More than 100 genetic variants that influence body mass index (measure of body size) or waist-to-hip ratio (measure of body shape) have been identified. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether genetic effects differ in older compared to younger adults, and whether such changes differ between men and women. Therefore, we conducted a systematic genome-wide search, including 114 studies (>320,000 individuals), to specifically identify genetic loci with age- and or sex-dependent effects on body size and shape. We identified 15 loci of which the effect on BMI was different in older compared to younger adults, whereas we found no evidence for loci with different effects in men compared to women. The opposite was seen for body shape as we identified 44 loci of which the effect on waist-to-hip ratio differed between men and women, but no difference between younger and older adults were observed. Our observations may provide new insights into the biology that underlies weight change with age or the sexual dimorphism of body shape.
Published in
PLoS Genetics
Volume
Volume: 11
DOI
http://dx.doi.org/10.1371/journal.pgen.1005378
ISSN
15537404
Subjects
Notes
Open access article
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
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