Biological interpretation of genome-wide association studies using predicted gene functions

Publication type

Journal Article

Authors

Publication date

January 15, 2015

Summary:

The main challenge for gaining biological insights from genetic
associations is identifying which genes and pathways explain the
associations. Here we present DEPICT, an integrative tool that employs
predicted gene functions to systematically prioritize the most likely
causal genes at associated loci, highlight enriched pathways and
identify tissues/cell types where genes from associated loci are highly
expressed. DEPICT is not limited to genes with established functions and
prioritizes relevant gene sets for many phenotypes.

Published in

Nature Communications

Volume

Volume: 6: 5890

DOI

http://dx.doi.org/10.1038/ncomms6890

ISSN

20411723

Subjects

Notes

Not held in Hilary Doughty Research Library - bibliographic reference only

#523014

News

Latest findings, new research

Publications search

Search all research by subject and author

Podcasts

Researchers discuss their findings and what they mean for society

Projects

Background and context, methods and data, aims and outputs

Events

Conferences, seminars and workshops

Survey methodology

Specialist research, practice and study

Taking the long view

ISER's annual report

Themes

Key research themes and areas of interest