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Journal Article

The transferability of lipid loci across African, Asian and European cohorts

Authors

Publication date

24 Sep 2019

Summary

Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p 

Published in

Nature Communications

Volume

10:4330

DOI

https://doi.org/10.1038/s41467-019-12026-7

ISSN

16

Subjects

Medicine, Demography, Ethnic Groups, Health, Biology, and Genetics

Notes

Open Access; This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.


Related publications

  1. The transferability of lipid-associated loci across African, Asian and European cohorts

    Nikita Telkar, Theresa Reiker, Robin G. Walters, et al.

    1. Medicine
    2. Demography
    3. Ethnic Groups
    4. Health
    5. Biology
    6. Genetics

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