Skip to content

Journal Article

Genome-wide physical activity interactions in adiposity ― a meta-analysis of 200,452 adults

Authors

  1. Mariaelisa Graff
  2. Robert A. Scott
  3. Anne E. Justice
  4. Kristin L. Young
  5. Mary F. Feitosa
  6. Llilda Barata
  7. Thomas W. Winkler
  8. Audrey Y. Chu
  9. Anubha Mahajan
  10. David Hadley
  11. Luting Xue
  12. Tsegaselassie Workalemahu
  13. Nancy L. Heard-Costa
  14. Marcel den Hoed
  15. Tarunveer S. Ahluwalia
  16. Qibin Qi
  17. Julius S. Ngwa
  18. Frida Renström
  19. Lydia Quaye
  20. John D. Eicher
  21. James E. Hayes
  22. Marilyn Cornelis
  23. Zoltán Kutalik
  24. Elise Lim
  25. Jian'an Luan
  26. Jennifer E. Huffman
  27. Weihua Zhang
  28. Wei Zhao
  29. Paula J. Griffin
  30. Toomas Haller
  31. Shafqat Ahmad
  32. Pedro M. Marques-Vidal
  33. Stephanie Bien
  34. Loic Yengo
  35. Alexander Teumer
  36. Albert Vernon Smith
  37. Meena Kumari
  38. Neergaard Marie Harder
  39. Justesen Marie Justesen
  40. Marcus E. Kleber
  41. Mette Hollensted
  42. Kurt Lohman
  43. Natalia V. Rivera
  44. John B. Whitfield
  45. Jing Hua Zhao
  46. Heather M. Stringham
  47. Leo-Pekka Lyytikainen
  48. Charlotte Huppertz
  49. Gonneke Willemsen
  50. Wouter J. Peyrot
  51. Ying Wu
  52. Kati Kristiansson
  53. Ayse Demirkan
  54. Myriam Fornage
  55. Maija Hassinen
  56. Lawrence F. Bielak
  57. Gemma Cadby
  58. Toshiko Tanaka
  59. Reedik Mägi
  60. Peter J. van der Most
  61. Anne U. Jackson
  62. Jennifer L. Bragg-Gresham
  63. Veronique Vitart
  64. Jonathan Marten
  65. Pau Navarro
  66. Claire Bellis
  67. Dorota Pasko
  68. Åsa Johansson
  69. Søren Snitker
  70. Yu-Ching Cheng
  71. Joel Eriksson
  72. Unhee Lim
  73. Mette Aadahl
  74. Linda S. Adair
  75. Najaf Amin
  76. Beverley Balkau
  77. Juha Auvinen
  78. John Beilby
  79. Richard N. Bergman
  80. Sven Bergmann
  81. Alain G. Bertoni
  82. John Blangero
  83. Amélie Bonnefond
  84. Lori L. Bonnycastle
  85. Judith B. Borja
  86. Søren Brage
  87. Fabio Busonero
  88. Steve Buyske
  89. Harry Campbell
  90. Peter S. Chines
  91. Francis S. Collins
  92. Tanguy Corre
  93. George Davey Smith
  94. Graciela E. Delgado
  95. Nicole Dueker
  96. Marcus Dörr
  97. Tapani Ebeling
  98. Gudny Eiriksdottir
  99. Tonu Esko
  100. Jessica D. Faul
  101. Mao Fu
  102. Kristine Færch
  103. Christian Gieger
  104. Sven Gläser
  105. Jian Gong
  106. Penny Gordon-Larsen
  107. Harald Grallert
  108. Tanja B. Grammer
  109. Niels Grarup
  110. Gerard van Grootheest
  111. Kennet Harald
  112. Nicholas D. Hastie
  113. Aki S. Havulinna
  114. Dena Hernandez
  115. Lucia Hindorff
  116. Lynne J. Hocking
  117. Oddgeir L. Holmens
  118. Christina Holzapfel
  119. Jouke Jan Hottenga
  120. Jie Huang
  121. Tao Huang
  122. Jennie Hui
  123. Cornelia Huth
  124. Nina Hutri-Kähönen
  125. Alan L. James
  126. John-Olov Jansson
  127. Min A. Jhun
  128. Markus Juonala
  129. Leena Kinnunen
  130. Heikki A. Koistinen
  131. Ivana Kolcic
  132. Pirjo Komulainen
  133. Johanna Kuusisto
  134. Kirsti Kvaløy
  135. Mika Kähönen
  136. Timo A. Lakka
  137. Lenore J. Launer
  138. Benjamin Lehne
  139. Cecilia M. Lindgren
  140. Mattias Lorentzon
  141. Robert Luben
  142. Michel Marre
  143. Yuri Milaneschi
  144. Keri L. Monda
  145. Grant W. Montgomery
  146. Marleen H. M. De Moor
  147. Antonella Mulas
  148. Martina Müller-Nurasyid
  149. A. W. Musk
  150. Reija Männikkö
  151. Satu Männistö
  152. Narisu Narisu
  153. Matthias Nauck
  154. Jennifer A. Nettleton
  155. Ilja M. Nolte
  156. Albertine J. Oldehinkel
  157. Matthias Olden
  158. Ken K. Ong
  159. Sandosh Padmanabhan
  160. Lavinia Paternoster
  161. Jeremiah Perez
  162. Markus Perola
  163. Annette Peters
  164. Ulrike Peters
  165. Patricia A. Peyser
  166. Inga Prokopenko
  167. Hannu Puolijoki
  168. Olli T. Raitakari
  169. Tuomo Rankinen
  170. Laura J. Rasmussen-Torvik
  171. Rajesh Rawal
  172. Paul M. Ridker
  173. Lynda M. Rose
  174. Igor Rudan
  175. Cinzia Sarti
  176. Mark A. Sarzynski
  177. Kai Savonen
  178. William R. Scott
  179. Serena Sanna
  180. Alan R. Shuldiner
  181. Steve Sidney
  182. Günther Silbernagel
  183. Blair H. Smith
  184. Jennifer A. Smith
  185. Harold Snieder
  186. Alena Stančáková
  187. Barbara Sternfeld
  188. Amy J. Swift
  189. Tuija Tammelin
  190. Sian-Tsung Tan
  191. Barbara Thorand
  192. Dorothée Thuillier
  193. Liesbeth Vandenput
  194. Henrik Vestergaard
  195. Jana V. van Vliet-Ostaptchouk
  196. Marie-Claude Vohl
  197. Uwe Völker
  198. Gérard Waeber
  199. Mark Walker
  200. Sarah Wild
  201. Andrew Wong
  202. Alan F. Wright
  203. M. Carola Zillikens
  204. Niha Zubair
  205. Christopher A. Haiman
  206. Loic Lemarchand
  207. Ulf Gyllensten
  208. Claes Ohlsson
  209. Albert Hofman
  210. Fernando Rivadeneira
  211. André G. Uitterlinden
  212. Louis Pérusse
  213. James F. Wilson
  214. Caroline Hayward
  215. Ozren Polasek
  216. Francesco Cucca
  217. Kristian Hveem
  218. Catharina A. Hartman
  219. Anke Tönjes
  220. Stefania Bandinelli
  221. Lyle J. Palmer
  222. Sharon L. R. Kardia
  223. Rainer Rauramaa
  224. Thorkild I. A. Sørensen
  225. Jaakko Tuomilehto
  226. Veikko Salomaa
  227. Brenda W. J. H. Penninx
  228. Eco J. C. de Geus
  229. Dorret I. Boomsma
  230. Terho Lehtimäki
  231. Massimo Mangino
  232. Markku Laakso
  233. Claude Bouchard
  234. Nicholas G. Martin
  235. Diana Kuh
  236. Yongmei Liu
  237. Allan Linneberg
  238. Winfried März
  239. Konstantin Strauch
  240. Mika Kivimäki
  241. Tamara B. Harris
  242. Vilmundur Gudnason
  243. Henry Völzke
  244. Lu Qi
  245. Marjo-Riitta Järvelin
  246. John C. Chambers
  247. Jaspal S. Kooner
  248. Philippe Froguel
  249. Charles Kooperberg
  250. Peter Vollenweider
  251. Goran Hallmans
  252. Torben Hansen
  253. Oluf Pedersen
  254. Andres Metspalu
  255. Nicholas J. Wareham
  256. Claudia Langenberg
  257. David R. Weir
  258. David J. Porteous
  259. Eric Boerwinkle
  260. Daniel I. Chasman
  261. Goncalo R. Abecasis
  262. Inês Barroso
  263. Mark I. McCarthy
  264. Timothy M. Frayling
  265. Jeffrey R. O'Connell
  266. Cornelia M. van Duijn
  267. Michael Boehnke
  268. Iris M. Heid
  269. Karen L. Mohlke
  270. David P. Strachan
  271. Caroline S. Fox
  272. Ching-Ti Liu
  273. Joel N. Hirschhorn
  274. Robert J. Klein
  275. Andrew D. Johnson
  276. Ingrid B. Borecki
  277. Paul W. Franks
  278. Kari E. North
  279. L. Adrienne Cupples
  280. Ruth J. F. Loos
  281. Tuomas O. Kilpeläinen

Publication date

2017

Summary

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Published in

PLoS Genetics

Volume

13

DOI

http://dx.doi.org/10.1371/journal.pgen.1006528

ISSN

16

Subjects

Health, Sport, Biology, and Genetics

Notes

Open Access; This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

#524447


Research home

Research home

News

Latest findings, new research

Publications search

Search all research by subject and author

Podcasts

Researchers discuss their findings and what they mean for society

Projects

Background and context, methods and data, aims and outputs

Events

Conferences, seminars and workshops

Survey methodology

Specialist research, practice and study

Taking the long view

ISER's annual report

Themes

Key research themes and areas of interest