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Journal Article

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Authors

  1. Helen R. Warren
  2. Evangelos Evangelou
  3. Claudia P. Cabrera
  4. He Gao
  5. Meixia Ren
  6. Borbala Mifsud
  7. Ioanna Ntalla
  8. Praveen Surendran
  9. Chunyu Liu
  10. James P. Cook
  11. Aldi T. Kraja
  12. Fotios Drenos
  13. Marie Loh
  14. Niek Verweij
  15. Jonathan Marten
  16. Ibrahim Karaman
  17. Marcelo P. Segura Lepe
  18. Paul F. O'Reilly
  19. Joanne Knight
  20. Harold Snieder
  21. Norihiro Kato
  22. Jiang He
  23. E. Shyong Tai
  24. M. Abdullah Said
  25. David Porteous
  26. Maris Alver
  27. Neil Poulter
  28. Martin Farrall
  29. Ron T. Gansevoort
  30. Sandosh Padmanabhan
  31. Reedik Mägi
  32. Alice Stanton
  33. John Connell
  34. Stephan J. L. Bakker
  35. Andres Metspalu
  36. Denis C. Shields
  37. Simon Thom
  38. Morris Brown
  39. Peter Sever
  40. Tonu Esko
  41. Caroline Hayward
  42. Danish Saleheen
  43. Rajiv Chowdhury
  44. John C. Chambers
  45. Daniel I. Chasman
  46. Aravinda Chakravarti
  47. Christopher Newton-Cheh
  48. Cecilia M. Lindgren
  49. Daniel Levy
  50. Jaspal S. Kooner
  51. Bernard Keavney
  52. Maciej Tomaszewski
  53. Nilesh J. Samani
  54. Joanna M. M. Howson
  55. Martin D. Tobin
  56. Patricia B. Munroe
  57. Georg B. Ehret
  58. Louise V. Wain
  59. Ahmad Vaez
  60. Rick Jansen
  61. Roby Joehanes
  62. Peter J. van der Most
  63. A. Mesut Erzurumluoglu
  64. Paul O'Reilly
  65. Lynda M. Rose
  66. Germaine C. Verwoert
  67. Jouke-Jan Hottenga
  68. Rona J. Strawbridge
  69. Dan E. Arking
  70. Shih-Jen Hwang
  71. Xiuqing Guo
  72. Zoltán Kutalik
  73. Stella Trompet
  74. Nick Shrine
  75. Alexander Teumer
  76. Janina S. Ried
  77. Joshua C. Bis
  78. Albert V. Smith
  79. Najaf Amin
  80. Ilja M. Nolte
  81. Leo-Pekka Lyytikainen
  82. Anubha Mahajan
  83. Nicholas J. Wareham
  84. Edith Hofer
  85. Peter K. Joshi
  86. Kati Kristiansson
  87. Michela Traglia
  88. Aki S. Havulinna
  89. Anuj Goel
  90. Mike A. Nalls
  91. Siim Sõber
  92. Dragana Vuckovic
  93. Jian'an Luan
  94. Fabiola Del Greco M
  95. Kristin L. Ayers
  96. Jaume Marrugat
  97. Daniela Ruggiero
  98. Lorna M. Lopez
  99. Teemu Niiranen
  100. Stefan Enroth
  101. Anne U. Jackson
  102. Christopher P. Nelson
  103. Jennifer E. Huffman
  104. Weihua Zhang
  105. Ilaria Gandin
  106. Sarah E. Harris
  107. Tatijana Zemonik
  108. Yingchang Lu
  109. Nabi Shah
  110. Martin H. de Borst
  111. Massimo Mangino
  112. Bram P. Prins
  113. Archie Campbell
  114. Ruifang Li-Gao
  115. Ganesh Chauhan
  116. Christopher Oldmeadow
  117. Goncalo Abecasis
  118. Maryam Abedi
  119. Caterina M. Barbieri
  120. Michael R. Barnes
  121. Chiara Batini
  122. Tineka Blake
  123. Michael Boehnke
  124. Erwin P. Bottinger
  125. Peter S. Braund
  126. Marco Brumat
  127. Harry Campbell
  128. Massimiliano Cocca
  129. Francis Collins
  130. Heather J. Cordell
  131. Jeffrey J. Damman
  132. Gail Davies
  133. Eco J. de Geus
  134. Renée de Mutsert
  135. Joris Deelen
  136. Yusuf Demirkale
  137. Alex S. F. Doney
  138. Marcus Dörr
  139. Teresa Ferreira
  140. Mattias Frånberg
  141. Vilmantas Giedraitis
  142. Christian Gieger
  143. Franco Giulianini
  144. Alan J. Gow
  145. Anders Hamsten
  146. Tamara B. Harris
  147. Albert Hofman
  148. Elizabeth G. Holliday
  149. Marjo-Riitta Jarvelin
  150. Åsa Johansson
  151. Andrew D. Johnson
  152. Antti Jula
  153. Mika Kähönen
  154. Sekar Kathiresan
  155. Kay-Tee Khaw
  156. Ivana Kolcic
  157. Seppo Koskinen
  158. Claudia Langenberg
  159. Marty Larson
  160. Lenore J. Launer
  161. Benjamin Lehne
  162. David C. M. Liewald
  163. Li Lin
  164. Lars Lind
  165. François Mach
  166. Chrysovalanto Mamasoula
  167. Cristina Menni
  168. Yuri Milaneschi
  169. Anna Morgan
  170. Andrew D. Morris
  171. Alanna C. Morrison
  172. Peter J. Munson
  173. Priyanka Nandakumar
  174. Quang Tri Nguyen
  175. Teresa Nutile
  176. Albertine J. Oldehinkel
  177. Ben A. Oostra
  178. Elin Org
  179. Aarno Palotie
  180. Guillaume Pare
  181. Alison Pattie
  182. Brenda W. J. H. Penninx
  183. Peter P. Pramstaller
  184. Olli T. Raitakari
  185. Kenneth Rice
  186. Paul M. Ridker
  187. Harriëtte Riese
  188. Samuli Ripatti
  189. Antonietta Robino
  190. Jerome I. Rotter
  191. Igor Rudan
  192. Yasaman Saba
  193. Aude Saint Pierre
  194. Cinzia F. Sala
  195. Antti-Pekka Sarin
  196. Reinhold Schmidt
  197. Rodney Scott
  198. Marc A. Seelen
  199. David Siscovick
  200. Rossella Sorice
  201. David J. Stott
  202. Johan Sundström
  203. Morris Swertz
  204. Kent D. Taylor
  205. Ioanna Tzoulaki
  206. Christophe Tzourio
  207. André G. Uitterlinden
  208. Uwe Völker
  209. Peter Vollenweider
  210. Sarah Wild
  211. Gonneke Willemsen
  212. Alan F. Wright
  213. Jie Yao
  214. Sébastien Thériault
  215. David Conen
  216. John Attia
  217. Stéphanie Debette
  218. Dennis O. Mook-Kanamori
  219. Eleftheria Zeggini
  220. Tim D. Spector
  221. Pim van der Harst
  222. Colin N. A. Palmer
  223. Anne-Claire Vergnaud
  224. Ruth J. F. Loos
  225. Ozren Polasek
  226. John M. Starr
  227. Giorgia Girotto
  228. Veronique Vitart
  229. Jaakko Tuomilehto
  230. Ulf Gyllensten
  231. Paul Knekt
  232. Ian J. Deary
  233. Marina Ciullo
  234. Roberto Elosua
  235. Bernard D. Keavney
  236. Andrew A. Hicks
  237. Robert A. Scott
  238. Paolo Gasparini
  239. Maris Laan
  240. Yongmei Liu
  241. Hugh Watkins
  242. Catharina A. Hartman
  243. Veikko Salomaa
  244. Daniela Toniolo
  245. Markus Perola
  246. James F. Wilson
  247. Helena Schmidt
  248. Jing Hua Zhao
  249. Terho Lehtimäki
  250. Cornelia M. van Duijn
  251. Vilmundur Gudnason
  252. Bruce M. Psaty
  253. Annette Peters
  254. Rainer Rettig
  255. Alan James
  256. J. Wouter Jukema
  257. David P. Strachan
  258. Walter Palmas
  259. Erik Ingelsson
  260. Dorret I. Boomsma
  261. Oscar H. Franco
  262. Murielle Bochud
  263. Paul Elliott
  264. Andrew P. Morris
  265. Mark J. Caulfield

Publication date

Jan 2017

Abstract

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.

Published in

Nature Genetics

Volume and page numbers

49 , 403 -415

DOI

http://dx.doi.org/10.1038/ng.3768

ISSN

16

Subjects

Medicine, Science And Technology, Health, Biology, and Genetics

Notes

Not held in Hilary Doughty Research Library - bibliographic reference only

#524176


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