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Journal Article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Authors

  1. Praveen Surendran
  2. Fotios Drenos
  3. Robin Young
  4. Helen Warren
  5. James P. Cook
  6. Alisa K. Manning
  7. Niels Grarup
  8. Xueling Sim
  9. Daniel R. Barnes
  10. Kate Witkowska
  11. James R. Staley
  12. Vinicius Tragante
  13. Taru Tukiainen
  14. Hanieh Yaghootkar
  15. Nicholas Masca
  16. Daniel F. Freitag
  17. Teresa Ferreira
  18. Olga Giannakopoulou
  19. Andrew Tinker
  20. Magdalena Harakalova
  21. Evelin Mihailov
  22. Chunyu Liu
  23. Aldi T. Kraja
  24. Sune Fallgaard Nielsen
  25. Asif Rasheed
  26. Maria Samuel
  27. Wei Zhao
  28. Lori L. Bonnycastle
  29. Anne U. Jackson
  30. Narisu Narisu
  31. Amy J. Swift
  32. Lorraine Southam
  33. Jonathan Marten
  34. Jeroen R. Huyghe
  35. Alena Stancakova
  36. Cristiano Fava
  37. Therese Ohlsson
  38. Angela Matchan
  39. Kathleen E. Stirrups
  40. Jette Bork-Jensen
  41. Anette P. Gjesing
  42. Jukka Kontto
  43. Markus Perola
  44. Susan Shaw-Hawkins
  45. Aki S. Havulinna
  46. He Zhang
  47. Louise A. Donnelly
  48. Christopher J. Groves
  49. N. William Rayner
  50. Matt J. Neville
  51. Neil R. Robertson
  52. Andrianos M. Yiorkas
  53. Karl-Heinz Herzig
  54. Eero Kajantie
  55. Weihua Zhang
  56. Sara M. Willems
  57. Lars Lannfelt
  58. Giovanni Malerba
  59. Nicole Soranzo
  60. Elisabetta Trabetti
  61. Niek Verweij
  62. Evangelos Evangelou
  63. Alireza Moayyeri
  64. Anne-Claire Vergnaud
  65. Christopher P. Nelson
  66. Alaitz Poveda
  67. Tibor V. Varga
  68. Muriel Caslake
  69. Anton J. M. de Craen
  70. Stella Trompet
  71. Jian 'an Luan
  72. Robert A. Scott
  73. Sarah E. Harris
  74. David C. M. Liewald
  75. Riccardo Marioni
  76. Cristina Menni
  77. Aliki-Eleni Farmaki
  78. Goran Hallmans
  79. Frida Renstrom
  80. Jennifer E. Huffman
  81. Maija Hassinen
  82. Stephen Burgess
  83. Ramachandran S. Vasan
  84. Janine F. Felix
  85. Maria Uria-Nickelsen
  86. Anders Malarstig
  87. Dermot F. Reilly
  88. Maarten Hoek
  89. Thomas F. Vogt
  90. Honghuang Lin
  91. Wolfgang Lieb
  92. Matthew Traylor
  93. Hugh S. Markus
  94. Heather M. Highland
  95. Anne E. Justice
  96. Eirini Marouli
  97. Jaana Lindstrom
  98. Matti Uusitupa
  99. Pirjo Komulainen
  100. Timo A. Lakka
  101. Rainer Rauramaa
  102. Ozren Polasek
  103. Igor Rudan
  104. Olov Rolandsson
  105. Paul W. Franks
  106. George Dedoussis
  107. Timothy D. Spector
  108. Pekka Jousilahti
  109. Satu Mannisto
  110. Ian J. Deary
  111. John M. Starr
  112. Claudia Langenberg
  113. Nick J. Wareham
  114. Morris J. Brown
  115. Anna F. Dominiczak
  116. John M. Connell
  117. J. Wouter Jukema
  118. Naveed Sattar
  119. Ian Ford
  120. Chris J. Packard
  121. Tonu Esko
  122. Reedik Magi
  123. Andres Metspalu
  124. Rudolf A. de Boer
  125. Peter van der Meer
  126. Pim van der Harst
  127. Giovanni Gambaro
  128. Erik Ingelsson
  129. Lars Lind
  130. Paul I. W. de Bakker
  131. Mattijs E. Numans
  132. Ivan Brandslund
  133. Cramer Christensen
  134. Eva R. B. Petersen
  135. Eeva Korpi-Hyovalti
  136. Heikki Oksa
  137. John C. Chambers
  138. Jaspal S. Kooner
  139. Alexandra I. F. Blakemore
  140. Steve Franks
  141. Marjo-Riitta Jarvelin
  142. Lise L. Husemoen
  143. Allan Linneberg
  144. Tea Skaaby
  145. Betina Thuesen
  146. Fredrik Karpe
  147. Jaakko Tuomilehto
  148. Alex S. F. Doney
  149. Andrew D. Morris
  150. Colin N. A. Palmer
  151. Oddgeir Lingaas Holmen
  152. Kristian Hveem
  153. Cristen J. Willer
  154. Tiinamaija Tuomi
  155. Leif Groop
  156. AnneMari Karajamaki
  157. Aarno Palotie
  158. Samuli Ripatti
  159. Veikko Salomaa
  160. Dewan S. Alam
  161. Abdulla al Shafi Majumder
  162. Emanuele Di Angelantonio
  163. Rajiv Chowdhury
  164. Mark I. McCarthy
  165. Neil Poulter
  166. Alice V. Stanton
  167. Peter Sever
  168. Philippe Amouyel
  169. Dominique Arveiler
  170. Stefan Blankenberg
  171. Jean Ferrieres
  172. Frank Kee
  173. Kari Kuulasmaa
  174. Martina Muller-Nurasyid
  175. Giovanni Veronesi
  176. Panos Deloukas
  177. Paul Elliott
  178. Eleftheria Zeggini
  179. Sekar Kathiresan
  180. Olle Melander
  181. Johanna Kuusisto
  182. Markku Laakso
  183. Sandosh Padmanabhan
  184. David J. Porteous
  185. Caroline Hayward
  186. Francis S. Collins
  187. Karen L. Mohlke
  188. Torben Hansen
  189. Oluf Pedersen
  190. Michael Boehnke
  191. Heather M. Stringham
  192. Philippe Frossard
  193. Christopher Newton-Cheh
  194. Martin D. Tobin
  195. Borge Gronne Nordestgaard
  196. Mark J. Caulfield
  197. Anubha Mahajan
  198. Andrew P. Morris
  199. Maciej Tomaszewski
  200. Nilesh J. Samani
  201. Danish Saleheen
  202. Folkert W. Asselbergs
  203. Cecilia M. Lindgren
  204. John Danesh
  205. Louise V. Wain
  206. Adam S. Butterworth
  207. Patricia B. Munroe

Publication date

Oct 2016

Summary

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ~155,063 samples for independent replication. We identified 30 new blood pressure– or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.

Published in

Nature Genetics

Volume and page numbers

48 , 1151 -1161

DOI

https://dx.doi.org/10.1038/ng.3654

ISSN

16

Subjects

Medicine, Science And Technology, Health, Biology, and Genetics

Links

University of Essex, Albert Sloman Library Periodicals *restricted to University of Essex registered users* - http://serlib0.essex.ac.uk/record=b1680801~S5

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