Skip to content

Journal Article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Authors

  1. Aysu Okbay
  2. Bart M. L. Baselmans
  3. Jan-Emmanuel De Neve
  4. Patrick Turley
  5. Mark Alan Fontana
  6. S. Fleur W. Meddens
  7. Richard Karlsson Linner
  8. Cornelius A. Rietveld
  9. Jaime Derringer
  10. Jacob Gratten
  11. James J. Lee
  12. Jimmy Z. Liu
  13. Ronald de Vlaming
  14. Jadwiga Buchwald
  15. Alana Cavadino
  16. Alexis C. Frazier-Wood
  17. Nicholas A. Furlotte
  18. Victoria Garfield
  19. Marie Henrike Geisel
  20. Juan R. Gonzalez
  21. Saskia Haitjema
  22. Robert Karlsson
  23. Sander W. van der Laan
  24. Karl-Heinz Ladwig
  25. Jari Lahti
  26. Sven J. van der Lee
  27. Penelope A. Lind
  28. Tian Liu
  29. Lindsay Matteson
  30. Evelin Mihailov
  31. Michael B. Miller
  32. Camelia C. Minica
  33. Ilja M. Nolte
  34. Dennis Mook-Kanamori
  35. Peter J. van der Most
  36. Christopher Oldmeadow
  37. Yong Qian
  38. Olli Raitakari
  39. Rajesh Rawal
  40. Anu Realo
  41. Rico Rueedi
  42. Borge Schmidt
  43. Albert V. Smith
  44. Evie Stergiakouli
  45. Toshiko Tanaka
  46. Kent Taylor
  47. Juho Wedenoja
  48. Juergen Wellmann
  49. Harm-Jan Westra
  50. Sara M. Willems
  51. Wei Zhao
  52. Najaf Amin
  53. Andrew Bakshi
  54. Patricia A. Boyle
  55. Samantha Cherney
  56. Simon R. Cox
  57. Gail Davies
  58. Oliver S. P. Davis
  59. Jun Ding
  60. Nese Direk
  61. Peter Eibich
  62. Rebecca T. Emeny
  63. Ghazaleh Fatemifar
  64. Jessica D. Faul
  65. Luigi Ferrucci
  66. Andreas Forstner
  67. Christian Gieger
  68. Richa Gupta
  69. Tamara B. Harris
  70. Juliette M. Harris
  71. Elizabeth G. Holliday
  72. Jouke-Jan Hottenga
  73. Philip L. De Jager
  74. Marika A. Kaakinen
  75. Eero Kajantie
  76. Ville Karhunen
  77. Ivana Kolcic
  78. Meena Kumari
  79. Lenore J. Launer
  80. Lude Franke
  81. Ruifang Li-Gao
  82. Marisa Koini
  83. Anu Loukola
  84. Pedro Marques-Vidal
  85. Grant W. Montgomery
  86. Miriam A. Mosing
  87. Lavinia Paternoster
  88. Alison Pattie
  89. Katja E. Petrovic
  90. Laura Pulkki-Raback
  91. Lydia Quaye
  92. Katri Raikkonen
  93. Igor Rudan
  94. Rodney J. Scott
  95. Jennifer A. Smith
  96. Angelina R. Sutin
  97. Maciej Trzaskowski
  98. Anna E. Vinkhuyzen
  99. Lei Yu
  100. Delilah Zabaneh
  101. John R. Attia
  102. David A. Bennett
  103. Klaus Berger
  104. Lars Bertram
  105. Dorret I. Boomsma
  106. Harold Snieder
  107. Shun-Chiao Chang
  108. Francesco Cucca
  109. Ian J. Deary
  110. Cornelia M. van Duijn
  111. Johan G. Eriksson
  112. Ute Bultmann
  113. Eco J. C. de Geus
  114. Patrick J. F. Groenen
  115. Vilmundur Gudnason
  116. Torben Hansen
  117. Catharine A. Hartman
  118. Claire M. A. Haworth
  119. Caroline Hayward
  120. Andrew C. Heath
  121. David A. Hinds
  122. Elina Hypponen
  123. William G. Iacono
  124. Marjo-Riitta Jarvelin
  125. Karl-Heinz Jockel
  126. Jaakko Kaprio
  127. Sharon L. R. Kardia
  128. Liisa Keltikangas-Jarvinen
  129. Peter Kraft
  130. Laura D. Kubzansky
  131. Terho Lehtimaki
  132. Patrik K. E. Magnusson
  133. Matt McGue
  134. Andres Metspalu
  135. Melinda Mills
  136. Renee de Mutsert
  137. Albertine J. Oldehinkel
  138. Gerard Pasterkamp
  139. Nancy L. Pedersen
  140. Robert Plomin
  141. Ozren Polasek
  142. Christine Power
  143. Stephen S. Rich
  144. Frits R. Rosendaal
  145. Hester M. den Ruijter
  146. David Schlessinger
  147. Helena Schmidt
  148. Rauli Svento
  149. Reinhold Schmidt
  150. Behrooz Z. Alizadeh
  151. Thorkild I. A. Sorensen
  152. Tim D. Spector
  153. Andrew Steptoe
  154. Antonio Terracciano
  155. A. Roy Thurik
  156. Nicholas J. Timpson
  157. Henning Tiemeier
  158. Andre G. Uitterlinden
  159. Peter Vollenweider
  160. Gert G. Wagner
  161. David R. Weir
  162. Jian Yang
  163. Dalton C. Conley
  164. George Davey Smith
  165. Albert Hofman
  166. Magnus Johannesson
  167. David I. Laibson
  168. Sarah E. Medland
  169. Michelle N. Meyer
  170. Joseph K. Pickrell
  171. Tonu Esko
  172. Robert F. Krueger
  173. Jonathan P. Beauchamp
  174. Philipp D. Koellinger
  175. Daniel J. Benjamin
  176. Meike Bartels
  177. David Cesarini

Publication date

Jun 2016

Summary

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n= 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Published in

Nature Genetics

Volume and page numbers

48 , 624 -633

DOI

https://dx.doi.org/10.1038/ng.3552

ISSN

16

Subjects

Psychology, Medicine, Science And Technology, Well Being, Health, and Biology

Links

University of Essex, Albert Sloman Library Periodicals *restricted to University of Essex registered users* - http://serlib0.essex.ac.uk/record=b1680801~S5


Related publications

  1. Scientists identify genes connected to wellbeing, depression and neuroticism

    Meena Kumari

  2. Genome shrinks uncover gene variants linked with sense of well-being

    Meena Kumari

  3. Genetic variants linked to well-being, depression, neuroticism identified

    Meena Kumari

#523618


Research home

Research home

News

Latest findings, new research

Publications search

Search all research by subject and author

Podcasts

Researchers discuss their findings and what they mean for society

Projects

Background and context, methods and data, aims and outputs

Events

Conferences, seminars and workshops

Survey methodology

Specialist research, practice and study

Taking the long view

ISER's annual report

Themes

Key research themes and areas of interest