New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Publication type

Journal Article

Authors

Publication date

February 1, 2016

Summary:

To increase our understanding of the genetic basis of adiposity and its
links to cardiometabolic disease risk, we conducted a genome-wide
association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF%
showed distinct cross-phenotype association signatures with a range of
cardiometabolic traits revealing new insights in the link between
adiposity and disease risk.

Published in

Nature Communications

Volume

Volume: 7:10495

DOI

http://dx.doi.org/10.1038/ncomms10495

ISSN

20411723

Subjects

Notes

Open Access article

#523585