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Journal Article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Authors

  1. Yingchang Lu
  2. Felix R. Day
  3. Stefan Gustafsson
  4. Martin L. Buchkovich
  5. Jianbo Na
  6. Diana L. Cousminer
  7. Zari Dastani
  8. Alexander W. Drong
  9. Tonu Esko
  10. David M. Evans
  11. Mario Falchi
  12. Mary F. Feitosa
  13. Teresa Ferreira
  14. Asa K. Hedman
  15. Robin Haring
  16. Pirro G. Hysi
  17. Mark M. Iles
  18. Anne E. Justice
  19. Stavroula Kanoni
  20. Vasiliki Lagou
  21. Rui Li
  22. Xin Li
  23. Adam Locke
  24. Chen Lu
  25. Reedik Mägi
  26. John R.B. Perry
  27. Tune H. Pers
  28. Qibin Qi
  29. Marianna Sanna
  30. Ellen M. Schmidt
  31. William R. Scott
  32. Dmitry Shungin
  33. Alexander Teumer
  34. Anna A.E. Vinkhuyzen
  35. Ryan W. Walker
  36. Harm-Jan Westra
  37. Mingfeng Zhang
  38. Weihua Zhang
  39. Jing Hua Zhao
  40. Zhihong Zhu
  41. Uzma Afzal
  42. Tarunveer Singh Ahluwalia
  43. Stephan J. L. Bakker
  44. Claire Bellis
  45. Amélie Bonnefond
  46. Katja Borodulin
  47. Aron S. Buchman
  48. Tommy Cederholm
  49. Audrey C. Choh
  50. Hyung Jin Choi
  51. Joanne E. Curran
  52. Lisette C.P.G.M. de Groot
  53. Philip L. De Jager
  54. Rosalie A.M. Dhonukshe-Rutten
  55. Anke W. Enneman
  56. Elodie Eury
  57. Daniel S. Evans
  58. Tom Forsen
  59. Nele Friedrich
  60. Frederic Fumeron
  61. Melissa E. Garcia
  62. Simone Gartner
  63. Bok-Ghee Han
  64. Aki S. Havulinna
  65. Caroline Hayward
  66. Dena Hernandez
  67. Hans Hillege
  68. Till Ittermann
  69. Jack W. Kent
  70. Ivana Kolcic
  71. Tiina Laatikainen
  72. Jari Lahti
  73. Irene Mateo Leach
  74. Christine G. Lee
  75. Jong-Young Lee
  76. Tian Liu
  77. Youfang Liu
  78. Stéphane Lobbens
  79. Marie Loh
  80. Leo-Pekka Lyytikainen
  81. Carolina Medina-Gomez
  82. Karl Michaëlsson
  83. Mike A. Nalls
  84. Carrie M. Nielson
  85. Laticia Oozageer
  86. Laura Pascoe
  87. Lavinia Paternoster
  88. Ozren Polasek
  89. Samuli Ripatti
  90. Mark A. Sarzynski
  91. Chan Soo Shin
  92. Nina Smolej Narancic
  93. Dominik Spira
  94. Priya Srikanth
  95. Elisabeth Steinhagen-Thiessen
  96. Yun Ju Sung
  97. Karin M.A. Swart
  98. Leena Taittonen
  99. Toshiko Tanaka
  100. Emmi Tikkanen
  101. Nathalie van der Velde
  102. Natasja M. van Schoor
  103. Niek Verweij
  104. Alan F. Wright
  105. Lei Yu
  106. Joseph M. Zmuda
  107. Niina Eklund
  108. Terrence Forrester
  109. Niels Grarup
  110. Anne U. Jackson
  111. Kati Kristiansson
  112. Teemu Kuulasmaa
  113. Johanna Kuusisto
  114. Peter Lichtner
  115. Jian'an Luan
  116. Anubha Mahajan
  117. Satu Männistö
  118. Cameron D. Palmer
  119. Janina S. Ried
  120. Robert A. Scott
  121. Alena Stancakova
  122. Peter J. Wagner
  123. Ayse Demirkan
  124. Angela Doring
  125. Vilmundur Gudnason
  126. Douglas P. Kiel
  127. Brigitte Kuhnel
  128. Massimo Mangino
  129. Barbara McKnight
  130. Cristina Menni
  131. Jeffrey R. O'Connell
  132. Ben A. Oostra
  133. Alan R. Shuldiner
  134. Kijoung Song
  135. Liesbeth Vandenput
  136. Cornelia M. van Duijn
  137. Peter Vollenweider
  138. Charles C. White
  139. Yvonne Boettcher
  140. Richard S. Cooper
  141. Nita G. Forouhi
  142. Christian Gieger
  143. Harald Grallert
  144. Aroon Hingorani
  145. Torben Jorgensen
  146. Pekka Jousilahti
  147. Mika Kivimaki
  148. Meena Kumari
  149. Claudia Langenberg
  150. Allan Linneberg
  151. Amy Luke
  152. Colin A. McKenzie
  153. Aarno Palotie
  154. Oluf Pedersen
  155. Annette Peters
  156. Konstantin Strauch
  157. Bamidele O. Tayo
  158. Nicholas J. Wareham
  159. David A. Bennett
  160. Lars Bertram
  161. John Blangero
  162. Matthias Bluher
  163. Claude Bouchard
  164. Harry Campbell
  165. Nam H. Cho
  166. Steven R. Cummings
  167. Stefan A. Czerwinski
  168. Ilja Demuth
  169. Rahel Eckardt
  170. Johan G. Eriksson
  171. Luigi Ferrucci
  172. Oscar H. Franco
  173. Philippe Froguel
  174. Ron T. Gansevoort
  175. Torben Hansen
  176. Tamara B. Harris
  177. Nicholas Hastie
  178. Markku Heliovaara
  179. Albert Hofman
  180. Joanne M. Jordan
  181. Antti Jula
  182. Mika Kahonen
  183. Eero Kajantie
  184. Paul B. Knekt
  185. Seppo Koskinen
  186. Peter Kovacs
  187. Terho Lehtimaki
  188. Lars Lind
  189. Yongmei Liu
  190. Eric S. Orwoll
  191. Clive Osmond
  192. Markus Perola
  193. Louis Perusse
  194. Olli T. Raitakari
  195. Tuomo Rankinen
  196. D.C. Rao
  197. Treva K. Rice
  198. Fernando Rivadeneira
  199. Igor Rudan
  200. Veikko Salomaa
  201. Thorkild I. A. Sørensen
  202. Michael Stumvoll
  203. Anke Tonjes
  204. Bradford Towne
  205. Gregory J. Tranah
  206. Angelo Tremblay
  207. Andre G. Uitterlinden
  208. Pim van der Harst
  209. Erkki Vartiainen
  210. Jorma S. Viikari
  211. Veronique Vitart
  212. Marie-Claude Vohl
  213. Henry Volzke
  214. Mark Walker
  215. Henri Wallaschofski
  216. Sarah Wild
  217. James F. Wilson
  218. Loic Yengo
  219. D. Timothy Bishop
  220. Ingrid B. Borecki
  221. John C. Chambers
  222. L. Adrienne Cupples
  223. Abbas Dehghan
  224. Panos Deloukas
  225. Ghazaleh Fatemifar
  226. Caroline Fox
  227. Terrence S. Furey
  228. Lude Franke
  229. Jiali Han
  230. David J. Hunter
  231. Juha Karjalainen
  232. Fredrik Karpe
  233. Robert C. Kaplan
  234. Jaspal S. Kooner
  235. Mark I. McCarthy
  236. Joanne M. Murabito
  237. Andrew P. Morris
  238. Julia A.N. Bishop
  239. Kari E. North
  240. Claes Ohlsson
  241. Ken K. Ong
  242. Inga Prokopenko
  243. J. Brent Richards
  244. Eric E. Schadt
  245. Tim D. Spector
  246. Elisabeth Widen
  247. Cristen J. Willer
  248. Jian Yang
  249. Erik Ingelsson
  250. Karen L. Mohlke
  251. Joel N. Hirschhorn
  252. John Andrew Pospisilik
  253. M. Carola Zillikens
  254. Cecilia Lindgren
  255. Tuomas Oskari Kilpelainen
  256. Ruth J. F. Loos

Publication date

01 Feb 2016

Summary

To increase our understanding of the genetic basis of adiposity and its
links to cardiometabolic disease risk, we conducted a genome-wide
association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF%
showed distinct cross-phenotype association signatures with a range of
cardiometabolic traits revealing new insights in the link between
adiposity and disease risk.

Published in

Nature Communications

Volume

7:10495

DOI

http://dx.doi.org/10.1038/ncomms10495

ISSN

16

Subjects

Medicine, Health, and Biology

Notes

Open Access article

#523585


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