Journal Article
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Authors
Publication date
01 Feb 2016
Summary
To increase our understanding of the genetic basis of adiposity and its
links to cardiometabolic disease risk, we conducted a genome-wide
association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF%
showed distinct cross-phenotype association signatures with a range of
cardiometabolic traits revealing new insights in the link between
adiposity and disease risk.
Published in
Nature Communications
Volume
7:10495
DOI
http://dx.doi.org/10.1038/ncomms10495
ISSN
16
Subjects
Notes
Open Access article
#523585