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Journal Article

Biological interpretation of genome-wide association studies using predicted gene functions

Authors

Publication date

Jan 2015

Summary

The main challenge for gaining biological insights from genetic
associations is identifying which genes and pathways explain the
associations. Here we present DEPICT, an integrative tool that employs
predicted gene functions to systematically prioritize the most likely
causal genes at associated loci, highlight enriched pathways and
identify tissues/cell types where genes from associated loci are highly
expressed. DEPICT is not limited to genes with established functions and
prioritizes relevant gene sets for many phenotypes.

Published in

Nature Communications

Volume

6: 5890

DOI

http://dx.doi.org/10.1038/ncomms6890

ISSN

16

Subjects

Medicine, Health, and Biology

Notes

Not held in Hilary Doughty Research Library - bibliographic reference only

#523014


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