Skip to content

Journal Article

The effect of Renin Angiotensin System genetic variants in acute pancreatitis

Authors

Publication date

Jan 2015

Summary

Objectives: We
sought association of genetic variants in the renin-angiotensin system
(RAS) and vitamin D system with acute pancreatitis (AP) development and
severity.Background: The endocrine RAS
is involved in circulatory homeostasis through the pressor action of
angiotensin II at its AT1 receptor. However, local RAS regulate growth
and inflammation in diverse cells and tissues, and their activity may be
suppressed by vitamin D. Intrapancreatic angiotensin II generation has
been implicated in the development of AP.Methods:
Five hundred forty-four white patients with AP from 3 countries (United
Kingdom, 22; Germany, 136; and The Netherlands 386) and 8487 control
subjects (United Kingdom 7833, The Netherlands 717) were genotyped for 8
polymorphisms of the RAS/vitamin D systems, chosen on the basis of
likely functionality.Results: The
angiotensin-converting enzyme I (rather than D) allele was significantly
associated with alcohol-related AP when all cohorts were combined (P =
0.03). The renin rs5707 G (rather than A) allele was associated with AP
(P = 0.002), infected necrosis (P = 0.025) and mortality (P = 0.046).Conclusions:
The association of 2 RAS polymorphisms with AP suggests the need for
further detailed analysis of the role of RAS/vitamin D in the genesis or
severity of AP, particularly given the ready potential for
pharmacological manipulation of this system using existing marketed
agents. However, further replication studies will be required before any
such association is considered robust, particularly given the
significant heterogeneity of AP causation and clinical course.(C) 2014 by Lippincott Williams & Wilkins.

Published in

Annals of Surgery

Volume and page numbers

261 , 180 -188

DOI

http://dx.doi.org/10.1097/SLA.0000000000000655

ISSN

16

Subjects

Medicine, Health, and Biology

Notes

Not held in Research Library - bibliographic reference only

#522604


Research home

Research home

News

Latest findings, new research

Publications search

Search all research by subject and author

Podcasts

Researchers discuss their findings and what they mean for society

Projects

Background and context, methods and data, aims and outputs

Events

Conferences, seminars and workshops

Survey methodology

Specialist research, practice and study

Taking the long view

ISER's annual report

Themes

Key research themes and areas of interest