Publication type
Journal Article
Authors
Publication date
December 15, 2014
Summary:
Context:
The hypothalamic pituitary-adrenal (HPA) axis is thought to play a role in Type 2 Diabetes (T2D). However, the evidence for an association between diurnal cortisol patterns and T2D is equivocal.
Objective:
The aim was to examine the association of cortisol patterns throughout the day with T2D status in a community-dwelling population.
Design:
This was a cross-sectional study of T2D status and salivary cortisol from phase 7 (2002–2004) of the Whitehall II study, United Kingdom.
Setting:
The occupational cohort was originally recruited in 1985–1988.
Participants:
3508 white men and women including 238 participants with T2D aged 50–74 years with complete information on cortisol secretion.
Outcome Measures:
We measured diurnal cortisol (nmol/l) patterns from six saliva samples obtained over the course of a normal day: at waking, +30 min, +2.5 h, +8 h, +12 h, and bedtime. The cortisol awakening response and slope in diurnal secretion were calculated.
Results:
T2D status was associated with a flatter slope in cortisol decline across the day (B = 0.004, C.I. = 0.001 to 0.007, p = 0.014) and greater bedtime cortisol (B = 0.063, C.I. = 0.010 to 0.117, p =0.020) independent of a wide range of covariates measured at the time of cortisol assessment. There was no association between morning cortisol, the cortisol awakening response and T2D (p > 0.05).
Conclusions:
In this non-clinical population, T2D was associated with a flatter slope in cortisol levels across the day and raised bedtime cortisol values.
Published in
The Journal of Clinical Endocrinology & Metabolism
Volume and page numbers
Volume: 99 , p.4 -4
DOI
http://dx.doi.org/10.1210/jc.2014-2459
ISSN
21972
Subjects
Notes
Not held in Research Library - bibliographic reference only
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