Template-type: ReDIF-Paper 1.0
Author-Name: Pudney, Stephen
Author-Name: Hernandez-Alava, Monica
Title: Copula-based modelling of self-reported health states: an application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease
Abstract: EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument generating a description of health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but little is known about the consequences of this change. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse the joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people affected by rheumatoid disease, and use it to generate mappings between the 3-level and 5-level descriptive systems. We find significant conflicts between the two, which would imply the reversal of an important conclusion in a real-world evaluation of drug therapies.

Creation-Date: 20160224
Number: 2016-04
Publication-Status: published
File-URL: https://www.iser.essex.ac.uk/wp-content/uploads/files/working-papers/iser/2016-04.pdf
File-Format: Application/pdf
Handle: RePEc:ese:iserwp:2016-04